Cartilage tissue engineering for degenerative joint disease☆

Tissue engineering of biphasic joint cartilage transplants.

In isolated posttraumatic or idiopathic joint defects the chondral layers and adjacent subchondral spongy bone are usually destructed. For regeneration we suggest the in vitro formation of a cartilage-coated biomaterial carriers (biphases) in order to fill the correspondingjoint defects. In this study Biocoral, a natural coralline material made of calcium carbonate, and calcite, a synthetic cal...

Nanomaterials for Cartilage Tissue Engineering

Feline degenerative joint disease.

OBJECTIVE To critically review and collate published information on feline degenerative joint disease (DJD) and identify areas in which information is lacking. STUDY DESIGN Critical literature review. METHODS Literature search through Pub Med, Commonwealth Agricultural Bureau Abstracts published in the English Language, or translated into English (January 1940-August 2008). RESULTS Althou...

Importance of Floating Chondrons in Cartilage Tissue Engineering

BACKGROUND Dedifferentiation of chondrocytes remains a major problem for cartilage tissue engineering. Chondrocytes loss differentiated phenotype in in vitro culture that is undesired for repair strategies. The chondrocyte is surrounded by a pericellular matrix (PCM), together forming the chondron. PCM has a positive effect on the maintenance of chondrocyte phenotype during culture in compar...

Engineering cartilage tissue.

Cartilage tissue engineering is emerging as a technique for the regeneration of cartilage tissue damaged due to disease or trauma. Since cartilage lacks regenerative capabilities, it is essential to develop approaches that deliver the appropriate cells, biomaterials, and signaling factors to the defect site. The objective of this review is to discuss the approaches that have been taken in this ...